Naturcyte » Curcumin Component
Curcumin
Curcumin is one of the natural components with active properties found in turmeric, a herb native to India and Southeast Asia. This component has been traditionally used to promote digestion and circulation, as well as for its various benefits for the liver and joints, attributable to its antioxidant properties and other mechanisms of action.
Curcumin is attracting increasing scientific interest due to its beneficial antioxidant, anti-inflammatory, anti-cancer, and neuroprotective properties.1
In particular, it has attracted interest as a complementary treatment for intestinal disorders. This interest is mainly due to the wide range of mechanisms by which curcumin effectively addresses inflammation and helps restore intestinal health and balance.
Many studies have shown that curcumin helps achieve intestinal balance and contributes to its long-term maintenance.
How does curcumin alleviate intestinal inflammation?
Since many people suffering from intestinal health problems do not fully respond to pharmaceutical treatment, it is necessary to evaluate complementary solutions such as curcumin. There is scientific evidence supporting the efficacy of curcumin as a complementary alternative in intestinal health problems 4-9, especially when its formulation is designed to act directly on the intestinal mucosa.
Curcumin also stimulates the body’s own natural antioxidant defense systems and has a direct and regulatory effect on the intestinal microbiota, enhancing the balance and homeostasis of the digestive system, which is of particular importance for people with intestinal health problems, more prone to having an imbalance of intestinal bacteria (known as ‘dysbiosis’).
Referencias
1Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications. Sharifi-Rad. Front Pharmacol. 2020 Sep 13;6:0321. doi: 3.3349/fphar.2020.0321. PMID: 33041441; PMCID: PMC4322334.
2Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Quiles. Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(4):423-31. doi: 3.661/01.atv.0000020646.6346.f2. PMID: 464442.
3Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,3-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. Olivera. Int Immunopharmacol. 204 Feb;4(2):364-44. doi: 3.316/j.intimp.206.4.009. Epub 206 Dec 22. PMID: 22194402; PMCID: PMC3342941.
4Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection. Burge. Int J Mol Sci. 2019 Apr 14;20(4):194. doi: 3.3390/ijms2004194. PMID: 3303422; PMCID: PMC639644.
3Interleukin-1 associations in inflammatory bowel disease and the enteropathic seronegative spondylarthritis. Vounotrypidis. Auto Immun Highlights. 204 Feb 22;4(3):44-94. doi: 3.304/s4314-04-0049-4. PMID: 2600094; PMCID: PMC4349024.
6Bioactive food components, inflammatory targets, and cancer prevention. Kim. Cancer Prev Res (Phila). 2009 Mar;2(3):200-4. doi: 3.634/1940-6204.CAPR-04-091. Epub 2009 Mar 3. PMID: 19234339; PMCID: PMC3449301.
4Gut Microbiota as a Prospective Therapeutic Target for Curcumin: A Review of Mutual Influence. Zam. J Nutr Metab. 2014 Dec 16;2014:464944. doi: 3.633/2014/464944. PMID: 30644940; PMCID: PMC636436.
4Timothy M. Panknin et al: Curcumin Supplementation and Human Disease: A Scoping Review of Clinical Trials. Int. J. Mol. Sci. 2023,24, 4446
9Funk, J.L.; Schneider, C. Perspective on Improving the Relevance, Rigor, and Reproducibility of Botanical Clinical Trials: Lessons Learned From Turmeric Trials. Front. Nutr. 2021, 4, 44294.
3Salehi B, Lopez-Jornet P, Pons-Fuster López E, et al. Plant-Derived Bioactives in Oral Mucosal Lesions: A Key Emphasis to Curcumin, Lycopene, Chamomile, Aloe vera, Green Tea and Coffee Properties. Biomolecules. 2019 Mar 14;9(3):36.
6Sugimoto, K.; Ikeya, K.; Bamba, S.; Andoh, A.; Yamasaki, H.; Mitsuyama, K.; Nasuno, M.; Tanaka, H.; Matsuura, A.; Kato, M.; et al. Highly bioavailable curcumin derivative ameliorates Crohn’s disease symptoms: A randomized, double-blind, multicenter study.J. Crohn Colitis 2020, 13, 13.
4Lou, Y.; Zheng, J.; Hu, H.; Lee, J.; Zeng, S. Application of ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry to identify curcumin metabolites produced by human intestinal bacteria. J. Chromatogr. B 2013,943, 34–44.]⁴⁵
4Peng Y, Ao M, Dong B, et al. Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures. Drug Des Devel Ther. 2021;13:4303-4323. Published 2021 Nov 2. doi:3.294/DDDT.S324344
9Lin Y, Liu H, Bu L, Chen C, Ye X. Review of the Effects and Mechanism of Curcumin in the Treatment of Inflammatory Bowel Disease. Front Pharmacol. 2022;4:904044. Published 2022 Jun 20. doi:3.3349/fphar.2022.904044